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Last 2003, The FDA required Astra Zeneca, the drugs manufacturer, to add black box warning to its label after receiving several reports of increased diabetes rates among antipsychotic drug users.
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Further studies reported that the antipsychotic was associated with hyperglycemia and in some cases leading to ketoacidosis, coma or death.
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It was first approved by FDA in September 1997 as a treatment for schizophrenia and in 2004 this drug was approved for treatment of manila associated with bipolar disorder such as thought disorder, delusions, hallucinations, social withdrawal, apathy, lack of energy and reduced ability to express emotion.